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Broflanilide (Ref: MCI-8007)
(Also known as: BAS 450 I)
SUMMARY
Broflanilide is an insecticide that is used to control chewing pests. It has a low aqueous solubility and is not considered to be highly volatile. In some situtions it may be very persistent in soil and in water systems. Whilst it is highly toxic to honeybees, It generally tends to have a low to moderate toxiciity to most other fauna and flora. It has a low oral mammalian toxicity snd no other human health concerns have been identified.
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
High alert:
Persistent
Warning:
Significant data are missing
Ecotoxicity
High alert:
Daphnia chronic ecotoxicity: High; Bees acute contact ecotoxicity: High; Bees acute oral ecotoxicity: High
Human health
Low alert
GENERAL INFORMATION
Description
A meta-diamide organo-halide insecticide that has larvicidal activity against many chewing pests
Example pests controlled
Chewing insect pests including termites, roaches and Spodoptera litura; Ants; Flies; Bedbugs
Example applications
Corn; Industrial, commercial and residential areas
Efficacy & activity
-
Availability status
Novel
Introduction & key dates
2020, first registration, Australia
UK regulatory status
UK COPR regulatory status
Not approved
Date COPR inclusion expires
Not applicable
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Not applicable
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
No
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
Australia, Canada, Mexico
Chemical structure
Isomerism
None
Chemical formula
C₂₅H₁₄BrF₁₁N₂O₂
Canonical SMILES
CN(C1=CC=CC(=C1F)C(=O)NC2=C(C=C(C=C2Br)C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F)C(=O)C3=CC=CC=C3
Isomeric SMILES
-
International Chemical Identifier key (InChIKey)
QSLZKWPYTWEWHC-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C25H14BrF11N2O2/c1-39(21(41)12-6-3-2-4-7-12)17-9-5-8-14(18(17)27)20(40)38-19-15(23(29,30)31)10-13(11-16(19)26)22(28,24(32,33)34)25(35,36)37/h2-11H,1H3,(H,38,40)
2D structure diagram/image available?
Yes
General status
Pesticide type
Insecticide, Larvicide
Substance groups
Diamide insecticide; Meta-diamide insecticide
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Metabolises to desmethyl-broflanilide which the acts as a noncompetitive resistant-to-dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor antagonist
CAS RN
1207727-04-5
EC number
688-148-8
CIPAC number
994
US EPA chemical code
-
PubChem CID
53341374
CLP index number
No data found
Molecular mass
663.3
PIN (Preferred Identification Name)
N-(2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-fluoro-3-(N-methylbenzamido)benzamide
IUPAC name
6'-bromo-α,α,α,2-tetrafluoro-3-(N-methylbenzamido)-4'-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)benz-o-toluidide
CAS name
3-(benzoylmethylamino)-N-(2-bromo-4-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)-6-(trifluoromethyl)phenyl)-2-fluorobenzamide
Other status information
This pesticide is a PFAS based on the US definition
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Classification (HRAC)
Not applicable
Herbicide Resistance Classification (WSSA)
Not applicable
Insecticide Resistance Classification (IRAC)
30
Fungicide Resistance Classification (FRAC)
Not applicable
Examples of recorded resistance
-
Physical state
White odourless powder
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • Mitsui Chemicals Agro Inc
  • BASF
Example products using this active
  • Vedira Granular fly bait
  • Vedira Gel Cockroach Bait
  • Vedira Pressurised Insecticide
  • Tenebenal
Formulation and application details
Available in a variety of different formultions including 'ready to use'
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
0.71
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
96.0
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
n-Heptane		 -
6000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Xylene		 -
7400
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
n-Octanol		 -
250000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Acetone		 -
Melting point (°C)
154.0
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 -
Boiling point (°C)
- - -
Degradation point (°C)
- - -
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
1.58 X 1005 Calculated -
Log P
5.2
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 High
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
- - -
Dissociation constant pKa) at 25 °C
8.8
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 -
-
Vapour pressure at 20 °C (mPa)
9.0 X 10-06
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
3.0 X 10-06
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Non-volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
Neutral soln: 239nm=17200, 274nm=5000, 282nm=4090
Acidic soln: 239nm=17000, 274nm=4980, 282nm=4120
Basic soln: 248nm=17600, 293nm=5560
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 -
Surface tension (mN m⁻¹)
- - -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
596
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Very persistent
DT₅₀ (lab at 20 °C)
596
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Very persistent
DT₅₀ (field)
107
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Persistent
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
DT₅₀ modelling endpoint
- - -
Note
Australian regulatory dossier: Lab studies degradation under aerobic conditions is slow. Field studies: DT₅₀ range 26-182 days.
Dissipation rate RL₅₀ on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
- - -
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Stable
Note
Stable at all relevant environmental pH values
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
- - -
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
- - -
Koc
-
Notes and range
-
Freundlich
Kf
- - -
Kfoc
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
- - -
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
Cannot be calculated - -
Note
-
Potential for particle bound transport index
- - -
Potential for loss via drain flow
- - -
Bio-concentration factor
BCF (l kg⁻¹)
189
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 Threshold for concern
CT₅₀ (days)
0.5 -
Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
desmethyl-broflanilid
- - -
Known groundwater metabolites

None

Other known metabolites

None
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 5000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rat		 Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
> 1000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Mouse		 Low
Birds - Acute LD₅₀ (mg kg⁻¹)
> 2000
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Unknown species		 Low
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
- - -
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
> 500
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Eisenia foetida corr		 Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
> 15
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Eisenia foetida corr		 Moderate
Soil micro-organisms
- - -
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Non-target plants
> 100
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Onion ryegrass wheat corn sugarbeet oilseed rape cabbage soybean lettuce and tomato
Emergence ER₅₀
as g ha⁻¹		 -
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
0.01
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera		 High
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
0.015
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera		 High
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic NOEL
> 0.00062
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera		 -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps)
- - -
Beneficial insects (Predatory mites)
- - -
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
0.25
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Lepomis macrochirus		 Moderate
Fish - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
> 0.33
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Daphnia magna		 Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
0.0058
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Daphnia magna		 High
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
> 0.63
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Lemna gibba		 Moderate
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
- - -
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 5000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rat		 Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
5000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rat		 -
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
- - -
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
- - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
-
Occupational
-
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
Rapid elimination, 90% within 4hrs of dosing
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
 -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
 No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
XNo, known not to cause a problem
 No data found
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Eye irritant Phototoxicant  
XNo, known not to cause a problem
 No data found  
General human health issues
Possible ovary toxicant
Handling issues
Property
Value and interpretation
General
Not explosive or oxidising
Not expected to autoignite; Not highly flammable
CLP classification 2013
-
WHO Classification
-
UN Number
-
Waste disposal & packaging
Not corrosive to packaging
Shelf-life, storage, stability and reactivity
-
TRANSLATIONS
Language
Name
English
broflanilide
French
broflanilide
German
-
Danish
-
Italian
-
Spanish
-
Greek
-
Polish
-
Swedish
-
Hungarian
-
Dutch
-
Norwegian
-
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